Atopica, Cequa, Cyclavance, Gengraf, Modulis, Neoral, Optimmune, Restasis, Sandimmune, Sporimune, Verkazia, Vevye Medication Summary
No separate FDA Medication Guide was found for this label. This summary is based on FDA/DailyMed prescribing information.
What is this medication?
This medication is described in FDA/DailyMed prescribing information. No separate FDA Medication Guide was found for this label. This summary is based on FDA/DailyMed prescribing information.
What is this medication used for?
Cyclosporine capsules, (NON-MODIFIED), in combination with adrenal corticosteroids, are indicated for the: Prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants.Treatment of chronic rejection in patients previously treated with other immunosuppressive agents.
What should I know before taking it?
Cyclosporine capsules are contraindicated in patients with a hypersensitivity reaction to cyclosporine or to any of the ingredients of the formulation.
What important warnings are listed?
Recommendations for Use Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe cyclosporine capsules, (NON-MODIFIED). Patients receiving cyclosporine capsules should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete information requisite for the follow-up of the patient. Use with Corticosteroids Cyclosporine capsules, (NON-MODIFIED) should be administered with adrenal corticosteroids but not with other immunosuppressive agents. Increased susceptibility to infection and the possible development of lymphoma.
How is this medication usually taken?
Patients with malabsorption may have difficulty in achieving therapeutic concentrations with cyclosporine capsules. Patients should be advised that a switch of their current cyclosporine formulation to another cyclosporine formulation should be made cautiously and only under health care provider supervision because it may result in the need for a change in dosage (see PRECAUTIONS and DOSAGE AND ADMINISTRATION). Patients should be informed of the necessity of repeated laboratory tests while they are receiving cyclosporine. They should be given careful dosage instructions, advised of the potential risks during pregnancy, and informed of the increased risk of neoplasia. Cyclosporine may impact.
What side effects are listed?
The principal adverse reactions of cyclosporine capsules therapy are renal dysfunction, tremor, hirsutism, hypertension, and gum hyperplasia. Hypertension Hypertension, which is usually mild to moderate, may occur in approximately 50% of patients following renal transplantation and in most cardiac transplant patients. Glomerular Capillary Thrombosis Glomerular capillary thrombosis has been found in patients treated with cyclosporine and may progress to graft failure. The pathologic changes resemble those seen in the hemolytic-uremic syndrome and include thrombosis of the renal microvasculature, with platelet-fibrin thrombi occluding glomerular capillaries and afferent arterioles,.
What interactions are listed?
A. Effect of Drugs and Other Agents on Cyclosporine Pharmacokinetics and/or Safety All of the individual drugs cited below are well substantiated to interact with cyclosporine. In addition, concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) with cyclosporine, particularly in the setting of dehydration, may potentiate renal dysfunction. Caution should be exercised when using other drugs which are known to impair renal function (see WARNINGS, Nephrotoxicity ).
Where can I find the official prescribing information?
Review the full prescribing information on DailyMed: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6
⚠️ Disclaimer
This summary is for educational purposes only and is not medical advice. Always consult your doctor, pharmacist, or other licensed healthcare professional before starting, stopping, or changing any medicine. Read full medical disclaimer.