Metoprolol Tartrate And Hydrochlorothiazide Medication Summary
No separate FDA Medication Guide was found for this label. This summary is based on FDA/DailyMed prescribing information.
What is this medication?
Metoprolol Tartrate and Hydrochlorothiazide is described in FDA/DailyMed prescribing information. No separate FDA Medication Guide was found for this label. This summary is based on FDA/DailyMed prescribing information.
What is this medication used for?
Metoprolol tartrate and hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including metoprolol. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve.
What should I know before taking it?
Metoprolol tartrate and hydrochlorothiazide tablets are contraindicated in patients with: Cardiogenic shock or decompensated heart failure.Sinus bradycardia, sick sinus syndrome, and greater than first-degree block unless a permanent pacemaker is in place.Anuria Hypersensitivity to metoprolol tartrate or hydrochlorothiazide or to other sulfonamide derived drugs.
What important warnings are listed?
5 WARNINGS AND PRECAUTIONS • Abrupt cessation may exacerbate myocardial ischemia. (5.1) • May worsen congestive heart failure. (5.2) • Bronchospasm: Avoid beta-blockers. (5.3) • Bradycardia. (5.4) • Avoid discontinuing therapy prior to major surgery. (5.5) • Diabetes: May mask symptoms of hypoglycemia and alter glucose levels; monitor. (5.6). • Monitor serum electrolytes and creatinine periodically. (5.7) • Peripheral vascular disease: Can aggravate symptoms of arterial insufficiency. (5.9) • Pheochromocytoma: First initiate therapy with an alpha blocker. (5.10) • Abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm. (5.11) • Patients may be unresponsive to the usual doses.
How is this medication usually taken?
Metoprolol tartrate and hydrochlorothiazide tablets, USP are supplied in the following strengths: 50 mg/25 mg: Tablets are white to off-white colored, round shaped, biconvex, bevel edged scored uncoated tablet debossed with “L” on one side of score line and “230” on another side of score line and plain on other side. 100 mg/25 mg: Tablets are white to off-white colored, oval shaped, biconvex, bevel edged scored uncoated tablet debossed with “L” on one side of score line and “232” on another side of score line and plain on other side. 100 mg/50 mg: Tablets are white to off-white colored, capsule shaped, biconvex, bevel edged scored uncoated tablet debossed with “L” on one side of score line.
What side effects are listed?
The following adverse reactions are described in more detail elsewhere in the label; Worsening angina or myocardial infarction [see Warnings and Precautions (5)] Worsening heart failure [see Warnings and Precautions (5)] Worsening AV block [see Contraindications (4)]
What interactions are listed?
7 DRUG INTERACTIONS Catecholamine-depleting drugs (e.g., MAO inhibitors): Hypotension, bradycardia. (7.1) CYP2D6 inhibitors: Increased metoprolol concentration. (12.3) Digitalis glycosides, clonidine, diltiazem and verapamil: Bradycardia. (5.4, 7.1) Clonidine: Rebound hypertension following clonidine withdrawal. (7.1) Antidiabetic drugs: Dosage adjustment may be required. (7.2) Cholestyramine and colestipol: Reduced absorption of thiazides. (7.2) Lithium: Risk of lithium toxicity. (7.2) Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects of diuretics. (7.2) 7.1 Drug Interactions with Metoprolol Catecholamine Depleting Drugs: The.
Where can I find the official prescribing information?
Review the full prescribing information on DailyMed: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2b77f66f-6891-4977-be8f-7955473d2f92
⚠️ Disclaimer
This summary is for educational purposes only and is not medical advice. Always consult your doctor, pharmacist, or other licensed healthcare professional before starting, stopping, or changing any medicine. Read full medical disclaimer.