Tizanidine R 180 55111 0180 15 Medication Summary
No separate FDA Medication Guide was found for this label. This summary is based on FDA/DailyMed prescribing information.
What is this medication?
This medication is described in FDA/DailyMed prescribing information. No separate FDA Medication Guide was found for this label. This summary is based on FDA/DailyMed prescribing information.
What is this medication used for?
Tizanidine tablet is a central alpha-2-adrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with tizanidine tablets should be reserved for those daily activities and times when relief of spasticity is most important [see Dosage and Administration ( 2.1) ].
What should I know before taking it?
Tizanidine hydrochloride is contraindicated in patients taking potent inhibitors of CYP1A2, such as fluvoxamine or ciprofloxacin [see Drug Interactions ( 7.1, 7.2 )].
What important warnings are listed?
Hypotension: monitor for signs and symptoms of hypotension, in particular in patients receiving concurrent antihypertensives; tizanidine hydrochloride should not be used with other α 2-adrenergic agonists ( 5.1, 7.7) Risk of liver injury: monitor ALTs; discontinue tizanidine hydrochloride if liver injury occurs ( 5.2) Sedation: tizanidine hydrochloride may interfere with everyday activities; sedative effects of tizanidine hydrochloride, alcohol, and other CNS depressants are additive ( 5.3, 7.5, 7.6) Hallucinations: consider discontinuation of tizanidine hydrochloride ( 5.4) Less potent inhibitors of CYP1A2: may cause hypotension, bradycardia, or excessive drowsiness, use caution if.
How is this medication usually taken?
Tablets Tizanidine Tablets USP, 4 mg are white to off white, oval, flat, beveled edged tablets debossed with “R180” on one side and “quadrisecting score” on other side.
What side effects are listed?
The following adverse reactions are described elsewhere in other sections of the prescribing information: Hypotension [see Warnings and Precautions ( 5.1) ] Liver Injury [see Warnings and Precautions ( 5.2) ] Sedation [see Warnings and Precautions ( 5.3) ] Hallucinosis/Psychotic-Like Symptoms [see Warnings and Precautions ( 5.4) ] Hypersensitivity Reactions [see Warnings and Precautions ( 5.6) ]
What interactions are listed?
Because of potential drug interactions, tizanidine hydrochloride is contraindicated in patients taking potent CYP1A2 inhibitors, such as fluvoxamine or ciprofloxacin. Adverse reactions such as hypotension, bradycardia, or excessive drowsiness can occur when tizanidine hydrochloride is taken with other CYP1A2 inhibitors, such as zileuton, fluoroquinolones other than ciprofloxacin (which is contraindicated), antiarrythmics (amiodarone, mexiletine, propafenone), cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine ). Concomitant use should be avoided unless the necessity for tizanidine hydrochloride therapy is clinically evident. In such a case, use with caution. [see Drug.
Where can I find the official prescribing information?
Review the full prescribing information on DailyMed: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bcc7f09-d2b5-4602-aaf3-5410b55ce275
⚠️ Disclaimer
This summary is for educational purposes only and is not medical advice. Always consult your doctor, pharmacist, or other licensed healthcare professional before starting, stopping, or changing any medicine. Read full medical disclaimer.